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Neurogenesis in the developing and adult brain- similarities and key differences

Götz, Magdalena, Nakafuku, Masato and Petrik, David 2016. Neurogenesis in the developing and adult brain- similarities and key differences. Cold Spring Harbor Perspectives in Biology 8 (7) , a018853. 10.1101/cshperspect.a018853

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Abstract

Adult neurogenesis in the mammalian brain is often viewed as a continuation of neurogenesis at earlier, developmental stages. Here, we will critically review the extent to which this is the case highlighting similarities as well as key differences. Although many transcriptional regulators are shared in neurogenesis at embryonic and adult stages, recent findings on the molecular mechanisms by which these neuronal fate determinants control fate acquisition and maintenance have revealed profound differences between development and adulthood. Importantly, adult neurogenesis occurs in a gliogenic environment, hence requiring adult-specific additional and unique mechanisms of neuronal fate specification and maintenance. Thus, a better understanding of the molecular logic for continuous adult neurogenesis provides important clues to develop strategies to manipulate endogenous stem cells for the purpose of repair.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Cold Spring Harbor Laboratory Press
ISSN: 1943-0264
Date of First Compliant Deposit: 10 September 2019
Date of Acceptance: 1 April 2016
Last Modified: 11 Sep 2019 09:30
URI: http://orca-mwe.cf.ac.uk/id/eprint/125388

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