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FXR regulates intestinal stem cells response to bile acids in a high fat diet

Parry, Lee and Phesse, Toby J 2019. FXR regulates intestinal stem cells response to bile acids in a high fat diet. Biotarget 3 (12) 10.21037/biotarget.2019.07.01

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Abstract

Although a high fat diet (HFD) is known to be associated with a poor clinical outcome for colorectal cancer (CRC) patients, the precise mechanisms underlying this are poorly understood. Fu and colleagues have recently identified high levels of bile acid (BA) in a preclinical mouse model of colon cancer, and that a HFD increases BA further which in turn promotes proliferation in Lgr5+ stem cells, via inhibition of farnesoid X receptor (FXR), to drive tumour progression (1).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: AME Publishing Company
ISSN: 2522-669X
Date of First Compliant Deposit: 10 July 2019
Date of Acceptance: 30 June 2019
Last Modified: 18 Oct 2019 17:18
URI: http://orca-mwe.cf.ac.uk/id/eprint/124140

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