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Local parasite pressures and host genotype modulate epigenetic diversity in a mixed-mating fish

Berbel-Filho, Waldir M, Garcia de Leaniz, Carlos, Moran, Paloma, Cable, Jo, Lima, Sergio M Q and Consuegra, Sofia 2019. Local parasite pressures and host genotype modulate epigenetic diversity in a mixed-mating fish. Ecology and Evolution 9 (15) , pp. 8736-8748. 10.1002/ece3.5426

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Parasite‐mediated selection is one of the main drivers of genetic variation in natural populations. The persistence of long‐term self‐fertilization, however, challenges the notion that low genetic variation and inbreeding compromise the host's ability to respond to pathogens. DNA methylation represents a potential mechanism for generating additional adaptive variation under low genetic diversity. We compared genetic diversity (microsatellites and AFLPs), variation in DNA methylation (MS‐AFLPs), and parasite loads in three populations of Kryptolebias hermaphroditus, a predomintanly self‐fertilizing fish, to analyze the potential adaptive value of DNA methylation in relation to genetic diversity and parasite loads. We found strong genetic population structuring, as well as differences in parasite loads and methylation levels among sampling sites and selfing lineages. Globally, the interaction between parasites and inbreeding with selfing lineages influenced DNA methylation, but parasites seemed more important in determining methylation levels at the local scale.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Wiley Open Access
ISSN: 2045-7758
Date of First Compliant Deposit: 8 July 2019
Date of Acceptance: 14 June 2019
Last Modified: 09 Sep 2019 10:51

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