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Determinants of long-term survival in a population-based cohort study of patients with head and neck cancer from Scotland

Ingarfield, K., McMahon, A.D., Douglas, C.M., Savage, S.A., Conway, D.I. and MacKenzie, K. 2019. Determinants of long-term survival in a population-based cohort study of patients with head and neck cancer from Scotland. Head and Neck 41 (6) , pp. 1908-1917. 10.1002/hed.25630

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Abstract

Background: We investigated long-term survival from head and neck cancer (HNC) using different survival approaches. Methods: Patients were followed-up from the Scottish Audit of Head and Neck Cancer. Overall survival and disease-specific survival were calculated using the Kaplan–Meier method. Net survival was calculated by the Pohar-Perme method.Mutually adjusted Cox proportional hazards models were used to determine the predictors of survival. Results: A total of 1820 patients were included in the analyses. Overall survival at 12 years was 26.3% (24.3%, 28.3%). Disease-specific survival at 12 years was 56.9% (54.3%, 59.4%). Net survival at 12 years was 41.4% (37.6%, 45.1%). Conclusion: Determinants associated with long-term survival included age, stage,treatment modality, WHO performance status, alcohol consumption, smoking behavior, and anatomical site. We recommend that net survival is used for long-term outcomes for HNC patients—it disentangles other causes of death, which are over estimated in overall survival and underestimated in disease-specific survival.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Centre for Trials Research (CNTRR)
Medicine
Publisher: Wiley
ISSN: 1043-3074
Date of Acceptance: 19 December 2018
Last Modified: 26 Sep 2019 10:59
URI: http://orca-mwe.cf.ac.uk/id/eprint/123969

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