Cardiorespiratory fitness is associated with increased middle cerebral arterial compliance and decreased cerebral blood flow in young healthy adults: a pulsed ASL MRI study

Furby, Hannah ORCID: https://orcid.org/0000-0002-7279-1812, Warnert, Esther, Marley, Christopher, Bailey, Damian and Wise, Richard ORCID: https://orcid.org/0000-0003-1700-2144 2020. Cardiorespiratory fitness is associated with increased middle cerebral arterial compliance and decreased cerebral blood flow in young healthy adults: a pulsed ASL MRI study. Journal of Cerebral Blood Flow and Metabolism 40 (9) , pp. 1879-1889. 10.1177/0271678X19865449

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Abstract

Cardiorespiratory fitness is thought to have beneficial effects on systemic vascular health, in part, by decreasing arterial stiffness. However, in the absence of non-invasive methods, it remains unknown whether this effect extends to the cerebrovasculature. The present study uses a novel pulsed arterial spin labelling (pASL) technique to explore the relationship between cardiorespiratory fitness and arterial compliance of the middle cerebral arteries (MCAC). Other markers of cerebrovascular health, including resting cerebral blood flow (CBF) and cerebrovascular reactivity to CO2 (CVRCO2) were also investigated. Eleven healthy males aged 21 ± 2 years with varying levels of cardiorespiratory fitness (maximal oxygen uptake (

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	SAGE
ISSN:	0271-678X
Date of First Compliant Deposit:	3 July 2019
Date of Acceptance:	12 June 2019
Last Modified:	06 Nov 2023 18:38
URI:	https://orca.cardiff.ac.uk/id/eprint/123966

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