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Microwave-assisted organic synthesis of nucleoside ProTide analogues

Bordoni, Cinzia, Cima, Cecilia Maria, Azzali, Elisa, Costantino, Gabriele and Brancale, Andrea 2019. Microwave-assisted organic synthesis of nucleoside ProTide analogues. RSC Advances 9 (35) , pp. 20113-20117. 10.1039/C9RA01754B

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Abstract

A microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5′-phosphoramidate synthesis, without protection of the 3′ position in the ribonucleoside.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Pharmacy
Publisher: Royal Society of Chemistry
ISSN: 2046-2069
Date of First Compliant Deposit: 27 June 2019
Date of Acceptance: 19 June 2019
Last Modified: 28 Jun 2019 10:45
URI: http://orca-mwe.cf.ac.uk/id/eprint/123783

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