Regional variations in quality of survival among men with prostate cancer across the United Kingdom

Donnelly, David W., Gavin, Anna, Downing, Amy, Hounsome, Luke, Kearney, Therese, McNair, Emma, Allan, Dawn, Huws, Dyfed W., Wright, Penny, Selby, Peter J., Kind, Paul, Watson, Eila, Wagland, Richard, Wilding, Sarah, Butcher, Hugh, Mottram, Rebecca, Allen, Majorie, McSorley, Oonagh, Sharp, Linda, Mason, Malcolm D. ORCID: https://orcid.org/0000-0003-1505-2869, Cross, William R., Catto, James W.F. and Glaser, Adam W. 2019. Regional variations in quality of survival among men with prostate cancer across the United Kingdom. European Urology 76 (2) , pp. 228-237. 10.1016/j.eururo.2019.04.018

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Abstract

BackgroundProstate cancer incidence, treatment, and survival rates vary throughout the UK, but little is known about regional differences in quality of survival.ObjectiveTo investigate variations in patient-reported outcomes between UK countries and English Cancer Alliances.Design, setting, and participantsA cross-sectional postal survey of prostate cancer survivors diagnosed 18–42 mo previously.Outcome measurements and statistical analysisUrinary, bowel, and sexual problems and vitality were patient reported using the Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire. General health was also self-assessed. Regional variations were identified using multivariable log-linear regression.Results and limitationsA total of 35 823 men responded, 60.8% of those invited. Self-assessed health was significantly lower than the UK average in Wales and Scotland. Respondents reported more urinary incontinence in Scotland, more urinary irritation/obstruction in Scotland and Northern Ireland (NI), poorer bowel function in Scotland and NI, worse sexual function in Scotland, and reduced vitality/hormonal function in Scotland, Wales, and NI. Self-assessed health was poorer than the English average in South Yorkshire and North-East and Cumbria, with more urinary incontinence in North-East and Cumbria and Peninsula, greater sexual problems in West Midlands, and poorer vitality in North-East and Cumbria and West Midlands. Limitations include difficulty identifying clinically significant differences and limited information on pretreatment conditions.ConclusionsDespite adjustment for treatment, and clinical and sociodemographic factors, quality of survival among prostate cancer survivors varied by area of residence. Adoption of best practice from areas performing well could support enhanced survival quality in poorer performing areas, particularly with regard to bowel problems and vitality, where clinically relevant differences were reported.Patient summaryWe conducted a UK-wide survey of patient's quality of life after treatment for prostate cancer. Outcomes were found to vary depending upon where patients live. Different service providers need to ensure that all prostate cancer patients receive the same follow-up care.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	0302-2838
Date of First Compliant Deposit:	6 June 2019
Date of Acceptance:	12 April 2019
Last Modified:	15 Nov 2023 02:36
URI:	https://orca.cardiff.ac.uk/id/eprint/123240

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