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Frailty predicts mortality in all emergency surgical admissions regardless of age. an observational study

Hewitt, J, Carter, B, McCarthy, K, Pearce, L, Law, J, Wilson, F V, Tay, H S, McCormack, C, Stechman, M J, Moug, S J and Myint, P K 2019. Frailty predicts mortality in all emergency surgical admissions regardless of age. an observational study. Age and Ageing 48 (3) , pp. 388-394. 10.1093/ageing/afy217
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Abstract

Abstract Background frail patients in any age group are more likely to die than those that are not frail. We aimed to evaluate the impact of frailty on clinical mortality, readmission rate and length of stay for emergency surgical patients of all ages. Methods a multi-centre prospective cohort study was conducted on adult admissions to acute surgical units. Every patient presenting as a surgical emergency to secondary care, regardless of whether they ultimately underwent a surgical procedure was included. The study was carried out during 2015 and 2016. Frailty was defined using the 7-point Clinical Frailty Scale. The primary outcome was mortality at Day 90. Secondary outcomes included: mortality at Day 30, length of stay and readmission within a Day 30 period. Results the cohort included 2,279 patients (median age 54 years [IQR 36–72]; 56% female). Frailty was documented in patients of all ages: 1% in the under 40’s to 45% of those aged 80+. We found that each incremental step of worsening frailty was associated with an 80% increase in mortality at Day 90 (OR 1.80, 95% CI: 1.61–2.01) supporting a linear dose–response relationship. In addition, the most frail patients were increasingly likely to stay in hospital longer, be readmitted within 30 days, and die within 30 days. Conclusions worsening frailty at any age is associated with significantly poorer patient outcomes, including mortality in unselected acute surgical admissions. Assessment of frailty should be integrated into emergency surgical practice to allow prognostication and implementation of strategies to improve outcomes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Oxford University Press (OUP)
ISSN: 0002-0729
Date of First Compliant Deposit: 7 March 2019
Date of Acceptance: 23 November 2018
Last Modified: 28 Jun 2019 20:19
URI: http://orca-mwe.cf.ac.uk/id/eprint/120343

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