Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Actin-related proteins in the nucleus: life beyond chromatin remodelers

Dion, Vincent, Shimada, Kenji and Gasser, Susan M 2010. Actin-related proteins in the nucleus: life beyond chromatin remodelers. Current Opinion in Cell Biology 22 (3) , 383--391. 10.1016/j.ceb.2010.02.006

Full text not available from this repository.

Abstract

Since their discovery in the mid-1990s, nuclear actin-related proteins (ARPs) have gained attention for their roles as structural components of ATP-dependent chromatin-remodeling complexes. These remodelers can move nucleosomes along the DNA, evict them from chromatin, and exchange histone variants to alter chromatin states locally. Chromatin-remodeling facilitates DNA-templated processes such as transcription regulation, DNA replication, and repair. Consistent with a role for ARPs in shaping chromatin structure, recent genetic studies show that they affect developmental and cell-type specific transcriptional programming. Here, we focus on recent results that suggest a specific contribution of ARPs to long-range interactions in the nucleus, and review evidence indicating that some ARPs may act independently of chromatin-remodeling machines.

Item Type: Article
Status: Published
Schools: Medicine
Publisher: Elsevier {BV}
ISSN: 0955-0674
Last Modified: 26 Mar 2019 11:13
URI: http://orca-mwe.cf.ac.uk/id/eprint/120293

Citation Data

Cited 50 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item