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Targeting the viral polymerase of diarrhea-causing viruses as a strategy to develop a single broad-spectrum antiviral therapy

Bassetto, Marcella, Van Dycke, Jana, Neyts, Johan, Brancale, Andrea and Rocha-Pereira, Joana 2019. Targeting the viral polymerase of diarrhea-causing viruses as a strategy to develop a single broad-spectrum antiviral therapy. Viruses 11 (2) , 173. 10.3390/v11020173

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Abstract

Viral gastroenteritis is an important cause of morbidity and mortality worldwide, being particularly severe for children under the age of five. The most common viral agents of gastroenteritis are noroviruses, rotaviruses, sapoviruses, astroviruses and adenoviruses, however, no specific antiviral treatment exists today against any of these pathogens. We here discuss the feasibility of developing a broad-spectrum antiviral treatment against these diarrhea-causing viruses. This review focuses on the viral polymerase as an antiviral target, as this is the most conserved viral protein among the diverse viral families to which these viruses belong to. We describe the functional and structural similarities of the different viral polymerases, the antiviral effect of reported polymerase inhibitors and highlight common features that might be exploited in an attempt of designing such pan-polymerase inhibitor.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Publisher: MDPI
ISSN: 1999-4915
Date of First Compliant Deposit: 4 March 2019
Date of Acceptance: 16 February 2019
Last Modified: 30 Apr 2019 17:26
URI: http://orca-mwe.cf.ac.uk/id/eprint/120154

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