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Ubiquitin-dependent chloroplast-associated protein degradation in plants

Ling, Qihua, Broad, William, Trösch, Raphael, Töpel, Mats, Demiral Sert, Tijen, Lymperopoulos, Panagiotis, Baldwin, Amy and Jarvis, R. Paul 2019. Ubiquitin-dependent chloroplast-associated protein degradation in plants. Science 363 (6429) , eaav4467. 10.1126/science.aav4467

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Abstract

Protein degradation is vital for cellular functions, and it operates selectively with distinct mechanisms in different organelles. Some organellar proteins are targeted by the ubiquitin-proteasome system (UPS)—a major proteolytic network in the eukaryotic cytosol. In such cases, the organelle membrane presents a substantial barrier to protein degradation. Working in the model plant Arabidopsis, Ling et al. identified mechanisms underlying the UPS-mediated degradation of proteins in the outer membrane of chloroplasts (the organelles responsible for photosynthesis). They identified an Omp85-type β-barrel outer membrane channel and a cytosolic AAA+ chaperone that fulfill conductance and motor functions in the retrotranslocation of target proteins from chloroplasts. This process thus enabled outer membrane protein processing by the cytosolic proteasome. Such chloroplast-associated protein degradation was initiated by ubiquitination of the targets by the chloroplast-localized E3 ubiquitin ligase SP1.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Date of Acceptance: 15 January 2019
Last Modified: 25 Feb 2019 12:15
URI: http://orca-mwe.cf.ac.uk/id/eprint/119780

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