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Effect of antibodies to glutamate on age-related memory changes in C57Bl/6 mice

Davydova, T. V., Gruden, M. A., Kudrin, V. S., Narkevich, V. B., Vetrile, L. A., Zakharova, I. A. and Sewell, Robert 2019. Effect of antibodies to glutamate on age-related memory changes in C57Bl/6 mice. Bulletin of Experimental Biology and Medicine 166 (3) , pp. 326-329. 10.1007/s10517-019-04343-0
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Chronic intranasal administration of antibodies to glutamate to aging C57Bl/6 mice improved passive avoidance conditioning, had no effect on horizontal and vertical locomotor activity, but slowed locomotion in the open-field test. Administration of antibodies to glutamate increased the content of dopamine and its metabolites in mouse hippocampus, but had no effect on the metabolism of neurotransmitter amino acids. In the frontal cortex, antibodies to glutamate did not affect neurotransmitter metabolism, but increased the level of both excitatory and inhibitory amino acids without changing their ratio.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Pharmacy
Publisher: Springer
ISSN: 0007-4888
Date of First Compliant Deposit: 14 February 2019
Date of Acceptance: 9 January 2019
Last Modified: 03 Jul 2019 11:07

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