The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro

Pepper, Christopher John, Thomas, Alun, Hoy, Terence George, Milligan, Donald, Bentley, Paul and Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 2003. The vitamin D3 analog EB1089 induces apoptosis via a p53-independent mechanism involving p38 MAP kinase activation and suppression of ERK activity in B-cell chronic lymphocytic leukemia cells in vitro. Blood 101 (7) , pp. 2454-2460. 10.1182/blood-2002-07-1984

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Abstract

EB1089, a novel vitamin D3 analog, has been shown to have cytotoxic and antiproliferative properties in a variety of malignant cells. However, its potential as a treatment for B-cell chronic lymphocytic leukemia (B-CLL) has not been evaluated. EB1089 induced apoptosis in all of the 102 B-CLL samples tested with a mean LD50 (the concentration of EB1089 required to kill 50% of cells) value (

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
ISSN:	15280020
Related URLs:	http://bloodjournal.hematologylibrary.or...
Last Modified:	04 Jun 2017 01:30
URI:	https://orca.cardiff.ac.uk/id/eprint/118

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