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Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

Cao, Qun, Howard, Joseph L., Crawford, Deborah E., James, Stuart L. and Browne, Duncan L. 2018. Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder. Green Chemistry 20 (19) , pp. 4443-4447. 10.1039/C8GC02036A

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Abstract

A study on the translation of a solid-state synthetic reaction from a mechanochemical mixer-mill to a continuous twin-screw extruder is discussed herein. The study highlights some considerations to be made and parameters to be tested in the context of a model fluorination reaction, which is the first organic fluorination to be attempted using extrusion. Upon optimization, which features the first use of grinding auxiliary solids to enable effective synthetic extrusion, the difluorination reaction was successfully translated to the extruder, leading to a 100-fold improvement in Space Time Yield (STY); 29 kg m−3 day−1 in a mixer mill to 3395 kg m−3 day−1 in a twin screw extruder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1463-9262
Funders: Engineering and Physical Sciences Research Council
Date of First Compliant Deposit: 25 September 2018
Date of Acceptance: 23 August 2018
Last Modified: 17 Oct 2019 02:37
URI: http://orca-mwe.cf.ac.uk/id/eprint/115233

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