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Mechanochemical activation of zinc and application to Negishi cross-coupling

Cao, Qun, Howard, Joseph L., Wheatley, Emilie and Browne, Duncan L. 2018. Mechanochemical activation of zinc and application to Negishi cross-coupling. Angewandte Chemie - International Edition 57 (35) , pp. 11339-11343. 10.1002/anie.201806480

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Abstract

A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross‐coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp3)–C(sp2) and C(sp2)–C(sp2) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochemical methods.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Wiley-Blackwell
ISSN: 1433-7851
Funders: EPSRC
Date of First Compliant Deposit: 25 September 2018
Date of Acceptance: 6 July 2018
Last Modified: 17 Oct 2019 02:37
URI: http://orca-mwe.cf.ac.uk/id/eprint/115231

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