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Loss of the thalamic nuclei for "head direction" impairs performance on spatial memory tasks in rats

Wilton, L. A. K., Baird, Alison Lambie, Muir, Janice L., Honey, Robert Colin and Aggleton, John Patrick 2001. Loss of the thalamic nuclei for "head direction" impairs performance on spatial memory tasks in rats. Behavioral Neuroscience 115 (4) , pp. 861-869. 10.1037/0735-7044.115.4.861

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Abstract

This study sought to characterize the effects of removing the nuclei of primary importance in relaying the thalamic head direction signal to the hippocampal formation (the anterior dorsal [AD] and lateral dorsal [LD] nuclei) on the performance of a variety of spatial and nonspatial tasks. The results indicate that combined excitotoxic lesions of the AD and LD nuclei produce marked deficits on a variety of spatial tasks. These tasks included T-maze alternation and the ability to locate a hidden platform set at a fixed distance and fixed direction from a beacon in a Morris water maze. Although object recognition appeared unaffected, marked impairments were found in the ability to detect when an object was placed in a novel position (object-in-place memory).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Psychology
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: American Psychological Association
ISSN: 0735-7044
Last Modified: 04 Jun 2017 02:43
URI: http://orca-mwe.cf.ac.uk/id/eprint/11400

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