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Virogenomics: a novel approach to antiviral drug discovery

Früh, Klaus, Simmen, Kenneth, Luukkonen, B.G.Mattias, Bell, Yolanda C and Ghazal, Peter 2001. Virogenomics: a novel approach to antiviral drug discovery. Drug Discovery Today 6 (12) , pp. 621-627. 10.1016/S1359-6446(01)01808-6

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Abstract

Target discovery in virology has been limited to the few open-reading frames encoded by viral genomes. However, several recent examples show that inhibiting host-cell proteins can prevent viral infection. The human genome sequence should, therefore, contain many more genes that are essential for viral propagation than viral genomes. A systematic approach to find these potential cellular antiviral targets is global host gene expression analysis using DNA microarrays. Several recent studies reveal both unique and common strategies by which viruses change the gene expression profile of the host cell. Moreover, work in progress shows that some of the host pathways discovered by expression profiling are important for viral replication. Thus, human genomics tools have the potential to deliver novel antiviral drugs.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 1359-6446
Last Modified: 31 Jul 2018 11:30
URI: http://orca-mwe.cf.ac.uk/id/eprint/113509

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