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HLA variation and disease

Dendrou, Calliope A., Petersen, Jan, Rossjohn, Jamie and Fugger, Lars 2018. HLA variation and disease. Nature Reviews Immunology 18 , pp. 325-339. 10.1038/nri.2017.143

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Fifty years since the first description of an association between HLA and human disease, HLA molecules have proven to be central to physiology, protective immunity and deleterious, disease-causing autoimmune reactivity. Technological advances have enabled pivotal progress in the determination of the molecular mechanisms that underpin the association between HLA genetics and functional outcome. Here, we review our current understanding of HLA molecules as the fundamental platform for immune surveillance and responsiveness in health and disease. We evaluate the scope for personalized antigen-specific disease prevention, whereby harnessing HLA–ligand interactions for clinical benefit is becoming a realistic prospect.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Nature Publishing Group
ISSN: 1474-1733
Last Modified: 19 Jul 2019 10:56

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