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High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover

Neller, M. A., Burrows, J. M., Rist, M. J., Miles, J. J. and Burrows, S. R. 2013. High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover. Journal of Virology 87 (1) , pp. 697-700. 10.1128/JVI.02180-12

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Abstract

High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus. Thus, in spite of exposure to a barrage of microorganisms over the course of life, the dominant clonotypes in the mature peripheral T cell repertoire can alter surprisingly little.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Society for Microbiology
ISSN: 0022-538X
Date of Acceptance: 13 October 2012
Last Modified: 08 May 2018 13:30
URI: http://orca-mwe.cf.ac.uk/id/eprint/110396

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