Calibrated fMRI for mapping absolute CMRO2: practicalities and prospects

Germuska, Michael ORCID: https://orcid.org/0000-0003-0580-4350 and Wise, Richard Geoffrey ORCID: https://orcid.org/0000-0003-1700-2144 2019. Calibrated fMRI for mapping absolute CMRO2: practicalities and prospects. NeuroImage 187 , pp. 145-153. 10.1016/j.neuroimage.2018.03.068

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Abstract

Functional magnetic resonance imaging (fMRI) is an essential workhorse of modern neuroscience, providing valuable insight into the functional organisation of the brain. The physiological mechanisms underlying the blood oxygenation level dependent (BOLD) effect are complex and preclude a straightforward interpretation of the signal. However, by employing appropriate calibration of the BOLD signal, quantitative measurements can be made of important physiological parameters including the the absolute rate of cerebral metabolic oxygen consumption or oxygen metabolism (CMRO2) and oxygen extraction (OEF). The ability to map such fundamental parameters has the potential to greatly expand the utility of fMRI and to broaden its scope of application in clinical research and clinical practice. In this review article we discuss some of the practical issues related to the calibrated-fMRI approach to the measurement of CMRO2. We give an overview of the necessary precautions to ensure high quality data acquisition, and explore some of the pitfalls and challenges that must be considered as it is applied and interpreted in a widening array of diseases and research questions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Uncontrolled Keywords:	BOLD, fMRI, CMRO2, OEF, oxygen metabolism, oxygen extraction, calibrated-fMRI, ASL, arterial spin labelling, hypercapnia, hyperoxia
Publisher:	Elsevier
ISSN:	1053-8119
Date of First Compliant Deposit:	28 March 2018
Date of Acceptance:	28 March 2018
Last Modified:	07 Nov 2023 05:12
URI:	https://orca.cardiff.ac.uk/id/eprint/110306

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