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Diversity oriented design of various hydrazides and their in vitro evaluation against Mycobacterium tuberculosis H37Rv strains

Manvar, Atul, Bavishi, Abhay, Radadiya, Ashish, Patel, Jignesh, Vora, Vipul, Dodia, Narshih, Rawal, Kena and Shah, Anamik 2011. Diversity oriented design of various hydrazides and their in vitro evaluation against Mycobacterium tuberculosis H37Rv strains. Biorganic and Medicinal Chemistry Letters 21 (16) , pp. 4728-4731. 10.1016/j.bmcl.2011.06.074

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Abstract

Control and prevention of tuberculosis is a major challenge, as one-third of the world’s population is infected with Mycobacterium tuberculosis. The resurgence of tuberculosis and the emergence of multidrug-resistance strains of mycobacteria, necessitate the search for new class of antimycobacterial agents. As a part of investigation of new antitubercular agents in this laboratory, we describe the syntheses of various hydrazides of comarins, quinolones and pyrroles and screening against M. tuberculosis (Mtb) H37Rv by using rifampin as a standard drug. Among the designed molecules, the most prominent compounds 2a–g, 4a and 9a showed >90% GI at MIC <6.25 μg/mL. Finally, these studies suggests that compounds 2a–g, 4a and 9a may serve as promising lead scaffolds for further generation of new anti-TB agents.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Elsevier
ISSN: 0960-894X
Date of Acceptance: 16 June 2011
Last Modified: 23 Mar 2018 11:08
URI: http://orca-mwe.cf.ac.uk/id/eprint/109867

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