Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures

McCafferty, Cian, David, Francois, Venzi, Marcello, Lorincz, Magor, Delicata, Francis, Atherton, Zoe, Recchia, Gregorio Egidio, Orban, Gergely, Lambert, Regis C, Di Giovanni, Giuseppe, Leresche, Nathalie and Crunelli, Vincenzo 2018. Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures. Nature Neuroscience 21 , pp. 744-756. 10.1038/s41593-018-0130-4

[img]
Preview
PDF - Supplemental Material
Download (76kB) | Preview
[img]
Preview
PDF - Accepted Post-Print Version
Download (245kB) | Preview
[img]
Preview
PDF - Supplemental Material
Download (7MB) | Preview
[img]
Preview
PDF - Supplemental Material
Download (2MB) | Preview

Abstract

Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives rise to the paroxysmal oscillations of absence seizures (ASs) remains unknown. Here we report that, during ASs in behaving animals, cortico-thalamic excitation drives thalamic firing by preferentially eliciting tonic rather than T-type Ca2+ channel (T-channel)-dependent burst firing in thalamocortical (TC) neurons and by temporally framing thalamic output via feedforward reticular thalamic (NRT)-to-TC neuron inhibition. In TC neurons, overall ictal firing was markedly reduced and bursts rarely occurred. Moreover, blockade of T-channels in cortical and NRT neurons suppressed ASs, but such blockade in TC neurons had no effect on seizures or on ictal thalamic output synchrony. These results demonstrate ictal bidirectional cortico-thalamic communications and provide the first mechanistic understanding of cortico-thalamo-cortical network firing dynamics during ASs in behaving animals.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Nature Publishing Group
ISSN: 1097-6256
Date of First Compliant Deposit: 13 March 2018
Date of Acceptance: 9 March 2018
Last Modified: 20 Oct 2019 05:54
URI: http://orca-mwe.cf.ac.uk/id/eprint/109829

Citation Data

Cited 17 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics