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A novel synthesis of tert-leucine via a Leuckart type reaction

Adger, Brian M., Dyer, Ulrich C., Lennon, Ian C., Tiffin, Peter D. and Ward, Simon 1998. A novel synthesis of tert-leucine via a Leuckart type reaction. Tetrahedron Letters 38 (12) , pp. 2153-2154. 10.1016/S0040-4039(97)00269-4

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Abstract

An efficient synthesis of racemic tert-leucine from trimethylpyruvic acid using a Leuckart type reaction is described. A facile resolution of an intermediate with α-methylbenzylamine allows entry into either (R)-or (S)-tert-leucine.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 0040-4039
Date of Acceptance: 7 February 1997
Last Modified: 23 Feb 2018 14:50
URI: http://orca-mwe.cf.ac.uk/id/eprint/109421

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