Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands-Part II

Ward, Simon, Eddershaw, Peter, Flynn, Sean T., Gordon, Laurie, Lovell, Peter J., Moore, Susan H., Scott, Claire M., Smith, Paul W., Thewlis, Kevin M. and Wyman, Paul A. 2008. Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands-Part II. Biorganic and Medicinal Chemistry Letters 19 (2) , pp. 428-432. 10.1016/j.bmcl.2008.11.052

Full text not available from this repository.

Abstract

A series of 5-(piperidinylethyloxy)quinoline 5-HT1 receptor ligands have been studied by elaboration of the series of dual 5-HT1-SSRIs reported previously. These new compounds display a different in vitro pharmacological profile with potent affinity across the 5-HT1A, 5-HT1B and 5-HT1D receptors and selectivity against the serotonin transporter. Furthermore, they have improved pharmacokinetic profiles and CNS penetration.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Uncontrolled Keywords: 5-HT1, SSRI, Serotonin, 5-HT1A antagonist, Depression
Publisher: Elsevier
ISSN: 0960-894X
Date of Acceptance: 14 November 2008
Last Modified: 21 Feb 2018 11:25
URI: http://orca-mwe.cf.ac.uk/id/eprint/109348

Citation Data

Cited 6 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item