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Recent advances in the discovery of selective and non-selective 5-HT1D receptor ligands

Ward, Simon and Watson, Jeannette M. 2010. Recent advances in the discovery of selective and non-selective 5-HT1D receptor ligands. Current Topics in Medicinal Chemistry 10 (5) , pp. 479-492. 10.2174/156802610791111533

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Abstract

This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT1D receptor. The field of 5-HT1D agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT1D receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor.

Item Type: Article
Status: Published
Schools: Medicine
Uncontrolled Keywords: 5-HT1D agonist, 5-HT1D antagonist, serotonin receptor, 5-HT receptor
Publisher: Bentham Science
ISSN: 1568-0266
Last Modified: 21 Feb 2018 11:14
URI: http://orca-mwe.cf.ac.uk/id/eprint/109344

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