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Nutraceuticals as therapeutic agents for atherosclerosis

Moss, Joe, Williams, Jessica and Ramji, Dipak 2018. Nutraceuticals as therapeutic agents for atherosclerosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1864 (5. A.) , pp. 1562-1572. 10.1016/j.bbadis.2018.02.006

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Abstract

Atherosclerosis, a chronic inflammatory disorder of medium and large arteries and an underlying cause of cardiovascular disease (CVD), is responsible for a third of all global deaths. Current treatments for CVD, such as optimized statin therapy, are associated with considerable residual risk and several side effects in some patients. The outcome of research on the identification of alternative pharmaceutical agents for the treatment of CVD has been relatively disappointing with many promising leads failing at the clinical level. Nutraceuticals, products from food sources with health benefits beyond their nutritional value, represent promising agents in the prevention of CVD or as an add-on therapy with current treatments. This review will highlight the potential of several nutraceuticals, including polyunsaturated fatty acids, flavonoids and other polyphenols, as anti-CVD therapies based on clinical and pre-clinical mechanism-based studies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0925-4439
Funders: British Heart Foundation
Date of First Compliant Deposit: 16 February 2018
Date of Acceptance: 12 February 2018
Last Modified: 28 Apr 2019 11:53
URI: http://orca-mwe.cf.ac.uk/id/eprint/109136

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