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Does endocardium modulate myocardial contractile performance?

Lewis, Malcolm John, Shah, Ajay M., Warden-Smith, Jeremy and Henderson, Andrew H. 1990. Does endocardium modulate myocardial contractile performance? Cardioscience 1 (2) , pp. 83-87.

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Abstract

It is now clear that the endocardium releases at least two agents which exert opposing effects on myocardial contraction. One appears to be endothelium-derived relaxing factor (EDRF), as in vascular endothelium, but the identity of the other is unknown. The mechanism by which these agents exert their characteristic but opposing effects on the duration of contraction likewise remains unknown. It is unlike that of other inotropic interventions and merits further investigation. Alterations in the time of onset of relaxation have important implications for diastolic filling.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Medicine
Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
ISSN: 1015-5007
Last Modified: 04 Jun 2017 02:12
URI: http://orca-mwe.cf.ac.uk/id/eprint/10868

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