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Key factors in breast cancer dissemination and establishment at the bone: past, present and future perspectives

Owen, Sioned, Zabkiewicz, Catherine, Ye, Lin, Sanders, Andrew, Gong, Chang and Jiang, Wen 2018. Key factors in breast cancer dissemination and establishment at the bone: past, present and future perspectives. In: Song, E and Hu, H eds. Translational Research in Breast Cancer:Biomarker Diagnosis, Targeted Therapies and Approaches to Precision, Vol. 1026. Advances in Experimental Medicine and Biology, Singapore: Kluwer, pp. 197-216. (10.1007/978-981-10-6020-5_9)

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Abstract

Bone metastases associated with breast cancer remain a clinical challenge due to their associated morbidity, limited therapeutic intervention and lack of prognostic markers. With a continually evolving understanding of bone biology and its dynamic microenvironment, many potential new targets have been proposed. In this chapter, we discuss the roles of well-established bone markers and how their targeting, in addition to tumour-targeted therapies, might help in the prevention and treatment of bone metastases. There are a vast number of bone markers, of which one of the best-known families is the bone morphogenetic proteins (BMPs). This chapter focuses on their role in breast cancer-associated bone metastases, associated signalling pathways and the possibilities for potential therapeutic intervention. In addition, this chapter provides an update on the role receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) play on breast cancer development and their subsequent influence during the homing and establishment of breast cancer-associated bone metastases. Beyond the well-established bone molecules, this chapter also explores the role of other potential factors such as activated leukocyte cell adhesion molecule (ALCAM) and its potential impact on breast cancer cells’ affinity for the bone environment, which implies that ALCAM could be a promising therapeutic target.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Kluwer
ISBN: 9789811060199
ISSN: 0065-2598
Funders: Cancer Research Wales, Life Sciences Research Network Wales (Welsh Government's Ser Cymru program), China Scholarship Council
Date of First Compliant Deposit: 26 July 2018
Last Modified: 28 May 2019 23:42
URI: http://orca-mwe.cf.ac.uk/id/eprint/107809

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