Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route?

Powell, Alison, Caterson, Bruce, Hughes, Clare, Paul, Alison, James, Craig, Hopkins, Stephen, Mansour, Omar and Griffiths, Peter 2017. Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route? Journal of Drug Targeting 25 (9-10) , pp. 919-926. 10.1080/1061186X.2017.1378660

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (733kB) | Preview

Abstract

The ability of a polymer therapeutic to access the appropriate subcellular location is crucial to its efficacy and is defined to a large part by the many and complex cellular biological and biochemical barriers such that a construct must traverse. It is shown here that model dextrin conjugates are able to pass through a cartilaginous extracellular matrix into chondrocytes, with little perturbation of the matrix structure, indicating that targeting of potential therapeutics through a cartilaginous extracellular matrix should be proven possible. Rapid chondrocytic targeting of drugs which require intra cellularisation for their activity and uniform extracellular concentrations of drugs with an extracellular target, is thus enabled though polymer conjugation.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Chemistry
Publisher: Informa Healthcare
ISSN: 1061-186X
Funders: Engineering and Physical Sciences Research Council
Date of First Compliant Deposit: 6 November 2017
Date of Acceptance: 8 September 2017
Last Modified: 28 Nov 2018 21:59
URI: http://orca-mwe.cf.ac.uk/id/eprint/106243

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics