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Patterns of retinal thickness prior to and following treatment with fluocinolone acetonide 190?µg intravitreal implant for diabetic macular edema

Currie, Craig, Holden, Sarah and Owens, David 2017. Patterns of retinal thickness prior to and following treatment with fluocinolone acetonide 190?µg intravitreal implant for diabetic macular edema. Current Medical Research and Opinion 33 (sup2) , pp. 33-43. 10.1080/03007995.2017.1366662

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Abstract

Objectives: To compare retinal thickness before and after treatment with the fluocinolone acetonide (FAc) 190 µg intravitreal implant in people with diabetic macular edema (DME) using data from the Iluvien Clinical Evidence study in the UK (ICE-UK). Methods: For this retrospective cohort study, data on people attending any one of 13 participating ophthalmology departments and treated with FAc intravitreal implant between April 1, 2013 and April 15, 2015 were collected for 12 months prior to and at least 12 months after implantation. Cross-sectional and longitudinal patterns of central foveal thickness (CFT) were compared before and after FAc implant. Results: There were 208 people who contributed data from 233 individual eyes treated with the FAc implant. Mean age was 68.1 years and 62% were male. Median (interquartile range) CFT decreased from 462 µm (354–603 µm) at time of implant to 309 µm (222–433 µm) at 12 months post-implant (p < .001). Over the same period, a reduction of ≥10%, ≥25%, and ≥50% in CFT was observed in 113 (65%), 87 (50%), and 37 (21%) treated eyes, respectively. Eyes with a CFT of ≥400 µm at the time of implant were significantly more likely to achieve a reduction in CFT of ≥10%, ≥25%, and ≥50% at 12 months (all p < .001) compared with eyes with a CFT of <400 µm at implant. Both retinal thickness and changes in retinal thickness were loosely correlated with visual acuity. Conclusion: A marked reduction in retinal thickness was observed in people following FAc intravitreal implant for DME. The response was related to the degree of retinal thickness prior to treatment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Informa Healthcare
ISSN: 0300-7995
Date of First Compliant Deposit: 31 January 2019
Last Modified: 25 Jul 2020 16:27
URI: http://orca-mwe.cf.ac.uk/id/eprint/105805

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