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Organoids, organs-on-chips and other systems, and microbiota

May, Stephanie, Evans, Samantha and Parry, Lee 2017. Organoids, organs-on-chips and other systems, and microbiota. Emerging Topics in Life Sciences 1 (4) , pp. 385-400. 10.1042/ETLS20170047

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Abstract

The human gut microbiome is considered an organ in its entirety and has been the subject of extensive research due to its role in physiology, metabolism, digestion, and immune regulation. Disequilibria of the normal microbiome have been associated with the development of several gastrointestinal diseases, but the exact underlying interactions are not well understood. Conventional in vivo and in vitro modelling systems fail to faithfully recapitulate the complexity of the human host–gut microbiome, emphasising the requirement for novel systems that provide a platform to study human host–gut microbiome interactions with a more holistic representation of the human in vivo microenvironment. In this review, we outline the progression and applications of new and old modelling systems with particular focus on their ability to model and to study host–microbiome cross-talk.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Publisher: Portland Press
ISSN: 2397-8554
Date of First Compliant Deposit: 19 October 2017
Date of Acceptance: 16 October 2017
Last Modified: 02 Feb 2018 16:26
URI: http://orca-mwe.cf.ac.uk/id/eprint/105680

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