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Cytokines in Atherosclerosis

Moss, Joe and Ramji, Dipak 2017. Cytokines in Atherosclerosis. In: Foti, Maria and Locati, Massimo eds. Cytokine Effector Functions in Tissues, Academic Press, pp. 109-118.

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Abstract

Cardiovascular disease, such as heart attacks and strokes, are still the world’s leading cause of morbidity and mortality worldwide. Atherosclerosis, an inflammatory disease of the medium and larger arteries in response to various risk factors such as hypertension and a build-up of modified low-density lipoproteins, is the underlying cause of cardiovascular disease. Cytokines are the key orchestrators of the chronic inflammatory response during atherosclerosis disease progression. There is therefore a need to develop a better understanding of the role of cytokines during disease progression in order to potentially discover novel drug targets. This chapter will focus on the role of pro- and anti-inflammatory cytokines during atherosclerosis plaque formation. Therapeutic avenues for targeting cytokine actions will also be discussed.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Academic Press
ISBN: 9780128042144
Date of Acceptance: 14 March 2017
Last Modified: 18 Oct 2017 13:49
URI: http://orca-mwe.cf.ac.uk/id/eprint/105458

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