Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Frizzled7: a promising achilles' heel for targeting the Wnt receptor complex to treat cancer

Phesse, Toby, Flanagan, Dustin and Vincan, Elizabeth 2016. Frizzled7: a promising achilles' heel for targeting the Wnt receptor complex to treat cancer. Cancers 8 (5) , p. 50. 10.3390/cancers8050050

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (825kB) | Preview

Abstract

Frizzled7 is arguably the most studied member of the Frizzled family, which are the cognate Wnt receptors. Frizzled7 is highly conserved through evolution, from Hydra through to humans, and is expressed in diverse organisms, tissues and human disease contexts. Frizzled receptors can homo- or hetero-polymerise and associate with several co-receptors to transmit Wnt signalling. Notably, Frizzled7 can transmit signalling via multiple Wnt transduction pathways and bind to several different Wnt ligands, Frizzled receptors and co-receptors. These promiscuous binding and functional properties are thought to underlie the pivotal role Frizzled7 plays in embryonic developmental and stem cell function. Recent studies have identified that Frizzled7 is upregulated in diverse human cancers, and promotes proliferation, progression and invasion, and orchestrates cellular transitions that underscore cancer metastasis. Importantly, Frizzled7 is able to regulate Wnt signalling activity even in cancer cells which have mutations to down-stream signal transducers. In this review we discuss the various aspects of Frizzled7 signalling and function, and the implications these have for therapeutic targeting of Frizzled7 in cancer.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: MDPI AG
ISSN: 2072-6694
Date of First Compliant Deposit: 3 October 2017
Date of Acceptance: 9 May 2016
Last Modified: 03 Oct 2017 10:32
URI: http://orca-mwe.cf.ac.uk/id/eprint/105126

Citation Data

Cited 34 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics