Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical and biological studies

Saeed, Hiwa K., Jarman, Paul J., Archer, Stuart, Sreedharan, Sreejesh, Saeed, Ibrahim Q., Mckenzie, Luke K., Weinstein, Julia A., Buurma, Niklaas J., Smythe, Carl G. W. and Thomas, Jim A. 2017. Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical and biological studies. Angewandte Chemie 56 (41) , pp. 12628-12633. 10.1002/anie.201707350

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Abstract

Using a new mononuclear “building block,” for the first time, a dinuclear RuII(dppn) complex and a heteroleptic system containing both RuII(dppz) and RuII(dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1O2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence “switch on” DNA light-switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Wiley-VCH Verlag
ISSN:	0044-8249
Date of First Compliant Deposit:	31 August 2017
Date of Acceptance:	18 August 2017
Last Modified:	31 Jan 2020 14:15
URI:	http://orca-mwe.cf.ac.uk/id/eprint/104169

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