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Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical and biological studies

Saeed, Hiwa, Jarman, Paul, Archer, Stuart, Sreedharan, Sreejesh, Saeed, Ibrahim, Mckenzie, Luke, Weinstein, Julia, Buurma, Niklaas, Smythe, Carl and Thomas, Jim Antony 2017. Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical and biological studies. Angewandte Chemie 56 (41) , pp. 12628-12633. 10.1002/anie.201707350

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Abstract

Using a new mononuclear “building block,” for the first time, a dinuclear RuII(dppn) complex and a heteroleptic system containing both RuII(dppz) and RuII(dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1O2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence “switch on” DNA light-switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Wiley-VCH Verlag
ISSN: 0044-8249
Date of First Compliant Deposit: 31 August 2017
Date of Acceptance: 18 August 2017
Last Modified: 29 Jun 2019 06:41
URI: http://orca-mwe.cf.ac.uk/id/eprint/104169

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