Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Capturing 'Extraordinary' soft-assembled charge-Like polypeptides as a strategy for nanocarrier design

Duro-Castano, Aroa, Nebot, Vicent J., Niño-Pariente, Amaya, Armiñán, Ana, Arroyo-Crespo, Juan J., Paul, Alison, Feiner-Gracia, Natalia, Albertazzi, Lorenzo and Vicent, María J. 2017. Capturing 'Extraordinary' soft-assembled charge-Like polypeptides as a strategy for nanocarrier design. Advanced Materials 29 (39) , 1702888. 10.1002/adma.201702888

[img]
Preview
PDF - Accepted Post-Print Version
Available under License Creative Commons Attribution.

Download (7MB) | Preview

Abstract

The rational design of nanomedicines is a challenging task given the complex architectures required for the construction of nanosized carriers with embedded therapeutic properties and the complex interface of these materials with the biological environment. Herein, an unexpected charge-like attraction mechanism of self-assembly for star-shaped polyglutamates in nonsalty aqueous solutions is identified, which matches the ubiquitous “ordinary–extraordinary” phenomenon previously described by physicists. For the first time, a bottom-up methodology for the stabilization of these nanosized soft-assembled star-shaped polyglutamates is also described, enabling the translation of theoretical research into nanomaterials with applicability within the drug-delivery field. Covalent capture of these labile assemblies provides access to unprecedented architectures to be used as nanocarriers. The enhanced in vitro and in vivo properties of these novel nanoconstructs as drug-delivery systems highlight the potential of this approach for tumor-localized as well as lymphotropic delivery.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Wiley-VCH
ISSN: 0935-9648
Date of First Compliant Deposit: 31 August 2017
Date of Acceptance: 6 July 2017
Last Modified: 22 Dec 2017 02:36
URI: http://orca-mwe.cf.ac.uk/id/eprint/104129

Citation Data

Cited 11 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics