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Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review)

Cai, Shuo, Cai, Jun, Jiang, Wen Guo and Ye, Lin 2017. Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review). International Journal of Molecular Medicine 40 (4) , pp. 965-971. 10.3892/ijmm.2017.3093

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Abstract

The mechanistic complexes of kinase D-interacting substrate of 220 kDa/ankyrin repeat-rich membrane spanning (Kidins220/ARMS) bind and integrate a variety of cellular cues to mediate neuronal activities such as neuronal differentiation, survival, and cytoskeleton remodelling by interacting with a variety of binding partners. Accumulated evidence has also indicated its role in the regulation of vascular development. Mice with Kidins220 knockdown phenotypically present with cardiovascular abnormalities. Kidins220 also contributes to immunomodulation in combination with B cells and T cells. Moreover, emerging evidence has revealed that this protein regulates many crucial cellular processes and thus has been implicated in an increasing number of malignancies. Here, we review recent advances in our understanding of Kidins220 and its role in cancer development. Further investigation is warranted to shed light on the role played by Kidins220 in the dynamic arrangement of the cytoskeleton and epithelial–mesenchymal transition, and its implication in tumourigenesis and cancer progression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Spandidos Publications
ISSN: 1107-3756
Date of First Compliant Deposit: 22 August 2017
Date of Acceptance: 20 July 2017
Last Modified: 10 Jan 2018 14:56
URI: http://orca-mwe.cf.ac.uk/id/eprint/103845

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