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Key molecular drivers of chronic lymphocytic leukemia

Alsagaby, Suliman A., Brennan, Paul and Pepper, Christopher 2016. Key molecular drivers of chronic lymphocytic leukemia. Clinical Lymphoma, Myeloma and Leukemia 16 (11) , pp. 593-606. 10.1016/j.clml.2016.08.008

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Abstract

Chronic lymphocytic leukemia (CLL) is an adult neoplastic disease of B cells characterized by variable clinical outcomes. Although some patients have an aggressive form of the disease and often encounter treatment failure and short survival, others have more stable disease with long-term survival and little or no need for theraphy. In the past decade, significant advances have been made in our understanding of the molecular drivers that affect the natural pathology of CLL. The present review describes what is known about these key molecules in the context of their role in tumor pathogenicity, prognosis, and therapy.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Uncontrolled Keywords: CLL, Molecular drivers, Pathogenicity, Prognosis, Therapy
Publisher: Elsevier
ISSN: 2152-2650
Date of Acceptance: 2 August 2016
Last Modified: 25 Feb 2019 22:59
URI: http://orca-mwe.cf.ac.uk/id/eprint/103720

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