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Myb via TGFβ is required for collagen type 1 production and skin integrity

Sampurno, Shienny, Cross, Ryan, Pearson, Helen, Kaur, Pritinder, Malaterre, Jordane and Ramsay, Robert G. 2015. Myb via TGFβ is required for collagen type 1 production and skin integrity. Growth Factors 33 (2) , pp. 102-112. 10.3109/08977194.2015.1016222

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Abstract

Skin integrity requires an ongoing replacement and repair orchestrated by several cell types. We previously investigated the architecture of the skin of avian myeloblastosis viral oncogene homolog (Myb) knock-out (KO) embryos and wound repair in Myb+/− mice revealing a need for Myb in the skin, attributed to fibroblast-dependent production of collagen type 1. Here, using targeted Myb deletion in keratin-14 (K14) positive cells we reveal further Myb-specific defects in epidermal cell proliferation, thickness and ultrastructural morphology. This was associated with a severe deficit in collagen type 1 production, reminiscent of that observed in patients with ichthyosis vulgaris and Ehlers–Danlos syndrome. Since collagen type 1 is a product of fibroblasts, the collagen defect observed was unexpected and appears to be directed by the loss of Myb with significantly reduced tumor growth factor beta 1 (Tgfβ−1) expression by primary keratinocytes. Our findings support a specific role for Myb in K14+ epithelial cells in the preservation of adult skin integrity and function.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Informa Healthcare
ISSN: 0897-7194
Date of Acceptance: 3 February 2015
Last Modified: 21 Aug 2017 10:07
URI: http://orca-mwe.cf.ac.uk/id/eprint/103600

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