Symptoms of Autism Spectrum Disorder (ASD) in individuals with Mucopolysaccharide Disease Type III (Sanfilippo Syndrome): a systematic review

Wolfenden, C., Wittkowski, A. and Hare, Dougal 2017. Symptoms of Autism Spectrum Disorder (ASD) in individuals with Mucopolysaccharide Disease Type III (Sanfilippo Syndrome): a systematic review. Journal of Autism and Developmental Disorders 47 (11) , pp. 3620-3633. 10.1007/s10803-017-3262-6

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Abstract

The prevalence of autism spectrum disorder (ASD) in many genetic disorders is well documented but not as yet in Mucopolysaccharidosis type III (MPS III). MPS III is a recessively inherited metabolic disorder and evidence suggests that symptoms of ASD present in MPS III. This systematic review examined the extant literature on the symptoms of ASD in MPS III and quality assessed a total of 16 studies. Results indicated that difficulties within speech, language and communication consistent with ASD were present in MPS III, whilst repetitive and restricted behaviours and interests were less widely reported. The presence of ASD-like symptoms can result in late diagnosis or misdiagnosis of MPS III and prevent opportunities for genetic counselling and the provision of treatments.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Publisher:	Springer
ISSN:	0162-3257
Date of First Compliant Deposit:	9 August 2017
Date of Acceptance:	23 July 2017
Last Modified:	07 Nov 2023 17:36
URI:	https://orca.cardiff.ac.uk/id/eprint/103431

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