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Reduced expression of RanBPM Is associated with poorer survival from lung cancer and increased proliferation and invasion of lung cancer cells in vitro

Zhao, Zehang, Cheng, Shan, Zabkiewicz, Catherine, Chen, Jinfeng, Zhang, Lijiang, Ye, Lin and Jiang, Wen G. 2017. Reduced expression of RanBPM Is associated with poorer survival from lung cancer and increased proliferation and invasion of lung cancer cells in vitro. Anticancer Research 37 (8) , pp. 4389-4397. 10.21873/anticanres.11833

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Abstract

Background/Aim: Ran binding protein microtubule-organizing centre (RanBPM), also known as RanBP9, is a scaffold protein conserved through evolution. We investigated the role of RanBPM in human lung cancer. Materials and Methods: Transcripts of RanBPM were determined in 56 human lung cancers along with paired normal lung tissues using real-time PCR. Association with prognosis was analyzed by online Kaplan–Meier survival analysis. In vitro lung cancer cell functional assays examined the impact of RanBPM-knockdown on cellular growth and invasion. Results: Higher expression of RanBPM was observed in tumor when compared to paired normal lung tissues. Increased RanBPM expression was seen in patients with longer overall and disease-free survival. Knockdown of RanBPM in lung cancer cell lines resulted in increased growth and invasion in vitro. Conclusion: Increased expression of RanBPM associates with postponed disease progression and better prognosis. RanBPM plays an inhibitory role in regulating proliferation and invasion of lung cancer cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: International Institute of Anticancer Research (IIAR)
ISSN: 0250-7005
Funders: Cancer Research Wales, Albert Hung Foundation, the Chinese Medical Research Studentship of Cardiff University.
Date of First Compliant Deposit: 15 January 2018
Date of Acceptance: 2 June 2017
Last Modified: 22 Jan 2018 12:22
URI: http://orca-mwe.cf.ac.uk/id/eprint/103039

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