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Application of non-invasive central aortic pressure assessment in clinical trials: clinical experience and value

Williams, Bryan, Brunel, Patrick, Lacy, Peter S., Baschiera, Fabio, Zappe, Dion H., Kario, Kazuomi and Cockcroft, John Ronald 2016. Application of non-invasive central aortic pressure assessment in clinical trials: clinical experience and value. Artery Research 17 , pp. 1-15. 10.1016/j.artres.2016.10.154

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Abstract

Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular (CV) events. However, recent clinical evidence suggests that central aortic pressure (CAP) provides additional information for assessing CV risk than brachial blood pressure (BrBP). Central hemodynamics can now be non-invasively assessed with a number of devices, however, the methodology employed to measure CAP, in order to better identify the patients at higher CV risk in clinical practice, is still controversial. The purpose of this article is to review the technology behind the non-invasive measurement of CAP via the effects of different classes of antihypertensive drugs on CAP and the data supporting the predictive value of assessing CAP on clinical outcomes, and to foster the transfer of methodological knowledge from clinical trials into routine clinical practice.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 1872-9312
Date of Acceptance: 19 October 2016
Last Modified: 23 May 2018 14:52
URI: http://orca-mwe.cf.ac.uk/id/eprint/102040

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