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Cytokine regulation of lung Th17 response to airway immunization using LPS adjuvant

Caucheteux, Stephane, Hu-Li, J, Mohammed, R N, Ager, Ann and Paul, W E 2016. Cytokine regulation of lung Th17 response to airway immunization using LPS adjuvant. Mucosal Immunology 10 (2) , pp. 361-372. 10.1038/mi.2016.54

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Abstract

Infections caused by bacteria in the airway preferentially induce a Th17 response. However, the mechanisms involved in the regulation of CD4 T-cell responses in the lungs are incompletely understood. Here, we have investigated the mechanisms involved in the regulation of Th17 differentiation in the lungs in response to immunization with lipopolysaccharide (LPS) as an adjuvant. Our data show that both Myd88 and TRIF are necessary for Th17 induction. This distinctive fate determination can be accounted for by the pattern of inflammatory cytokines induced by airway administration of LPS. We identified the production of interleukin (IL)-1β and IL-6 by small macrophages and IL-23 by alveolar dendritic cells (DCs), favoring Th17 responses, and IL-10 repressing interferon (IFN)-γ production. Furthermore, we show that exogenous IL-1β can drastically alter Th1 responses driven by influenza and lymphocytic choriomeningitis virus infection models and induce IL-17 production. Thus, the precision of the lung immune responses to potential threats is orchestrated by the cytokine microenvironment, can be repolarized and targeted therapeutically by altering the cytokine milieu. These results indicate that how the development of Th17 responses in the lung is regulated by the cytokines produced by lung DCs and macrophages in response to intranasal immunization with LPS adjuvant.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Nature Publishing Group
ISSN: 1933-0219
Funders: NIAID
Date of First Compliant Deposit: 27 June 2017
Date of Acceptance: 10 May 2016
Last Modified: 04 Apr 2020 08:24
URI: http://orca-mwe.cf.ac.uk/id/eprint/101799

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