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Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ

Ruffino, J. S., Davies, N. A., Morris, K., Ludgate, Marian, Zhang, Lei, Webb, R. and Thomas, A. W. 2016. Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ. European Journal of Applied Physiology 116 (9) , pp. 1671-1682. 10.1007/s00421-016-3414-y

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Abstract

Monocytes may be primed towards differentiation into classically activated M1 macrophages or alternatively activated M2 macrophages. M1 macrophages greatly contribute to the inflammation which promotes insulin resistance, whereas M2 macrophages resolve inflammation. We have previously shown that exercise increases M2 marker expression in mixed mononuclear cells, possibly via activation of the nuclear transcription factor PPARγ. However, these effects have not been demonstrated specifically within monocytes. Thus, we aimed to investigate whether moderate-intensity exercise elicited similar effects on monocytic M1/M2 marker expression and PPARγ activity to those reported previously in mononuclear cells, so as to further elucidate the mechanisms by which exercise may alter inflammatory status and, accordingly, prevent insulin resistance.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Springer
ISSN: 1439-6319
Funders: National Institute for Social Care and Health Research
Date of First Compliant Deposit: 27 June 2017
Date of Acceptance: 6 June 2016
Last Modified: 29 Aug 2017 12:52
URI: http://orca-mwe.cf.ac.uk/id/eprint/101764

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