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Polygenic risk score analysis of pathologically confirmed alzheimer's disease

Escott-Price, Valentina, Myers, Amanda J, Huentelman, Matt and Hardy, John 2017. Polygenic risk score analysis of pathologically confirmed alzheimer's disease. Annals of Neurology 82 (2) , pp. 311-314. 10.1002/ana.24999

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Abstract

Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzheimer’s disease have given Area Under the Curve estimates of <80%. However, these have been based on the genetic analysis of clinical case control series. Here we apply the same analytic approaches to a pathological case control series and show a predictive AUC of 84%. We suggest that this analysis has clinical utility and that there is limited room for further improvement using genetic data.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Alzheimer’s disease, genetics, pathology
Publisher: Wiley
ISSN: 0364-5134
Date of First Compliant Deposit: 21 June 2017
Date of Acceptance: 18 July 2017
Last Modified: 20 Jul 2018 19:40
URI: http://orca-mwe.cf.ac.uk/id/eprint/101628

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