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Helminth immunomodulation in autoimmune disease

Smallwood, Taylor B., Giacomin, Paul R., Loukas, Alex, Mulvenna, Jason P., Clark, Richard J. and Miles, John James 2017. Helminth immunomodulation in autoimmune disease. Frontiers in Immunology 10.3389/fimmu.2017.00453

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Abstract

Helminths have evolved to become experts at subverting immune surveillance. Through potent and persistent immune tempering, helminths can remain undetected in human tissues for decades. Redirecting the immunomodulating “talents” of helminths to treat inflammatory human diseases is receiving intensive interest. Here, we review therapies using live parasitic worms, worm secretions, and worm-derived synthetic molecules to treat autoimmune disease. We review helminth therapy in both mouse models and clinical trials and discuss what is known on mechanisms of action. We also highlight current progress in characterizing promising new immunomodulatory molecules found in excretory/secretory products of helminths and their potential use as immunotherapies for acute and chronic inflammatory diseases.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology > QR180 Immunology
Uncontrolled Keywords: helminthic therapy, autoimmunity, immunomodulation, excretory/secretory products, immunotherapy
Publisher: Frontiers Research Foundation
ISSN: 1664-3224
Date of First Compliant Deposit: 30 May 2017
Date of Acceptance: 3 April 2017
Last Modified: 12 Jun 2017 12:57
URI: http://orca-mwe.cf.ac.uk/id/eprint/100989

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