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Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the first workshop on drug transporters in the lungs

Ehrhardt, Carsten, Bäckman, Per, Couet, William, Edwards, Chris, Forbes, Ben, Fridén, Markus, Gumbleton, Mark, Hosoya, Ken-Ichi, Kato, Yukio, Nakanishi, Takeo, Takano, Mikihisa, Terasaki, Tetsuya and Yumoto, Ryoko 2017. Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the first workshop on drug transporters in the lungs. Journal of Pharmaceutical Sciences 106 (9) , pp. 2234-2244.

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Abstract

The School of Pharmacy and Pharmaceutical Sciences at Trinity College Dublin hosted the “1st Workshop on Drug Transporters in the Lungs” in September 2016 to discuss the impact of transporters on pulmonary drug disposition and their roles as drug targets in lung disease. The workshop brought together about 30 scientists from academia and pharmaceutical industry from Europe and Japan and addressed the primary questions: What do we know today, and what do we need to know tomorrow about transporters in the lung? The 3 themes of the workshop were: (1) techniques to study drug transporter expression and actions in the lungs; (2) drug transporter effects on pulmonary pharmacokinetics—case studies; and (3) transporters as drug targets in lung disease. Some of the conclusions of the workshop were: suitable experimental models that allow studies of transporter effects are available; data from these models convincingly show a contribution of both uptake and efflux transporters on pulmonary drug disposition; the effects of transporters on drug lung PK is now better conceptualized; some transporters are associated with lung diseases. However, more work is needed to establish which of the available models best translate to the clinical situation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Uncontrolled Keywords: absorption; computational ADME; efflux pumps; in vitro models; organic cation transporters; P-glycoprotein; peptide transporters; pulmonary delivery/absorption; ABC transporters; organic anion-transporting polypeptide transporters
Publisher: WileyBlackwell
ISSN: 0022-3549
Date of First Compliant Deposit: 30 May 2017
Date of Acceptance: 7 April 2017
Last Modified: 24 Jan 2019 15:05
URI: http://orca-mwe.cf.ac.uk/id/eprint/100958

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