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The role of HLA-class I heavy-chain interactions with killer-cell immunoglobulin-like receptors in immune regulation

Kollnberger, Simon 2016. The role of HLA-class I heavy-chain interactions with killer-cell immunoglobulin-like receptors in immune regulation. Critical Reviews in Immunology 36 (3) , pp. 269-282. 10.1615/CritRevImmunol.2016017965

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HLA-class I molecules form trimeric complexes (pMHC) of peptides, class I heavy chains, and β2microglobulins (β2m) that regulate immune responses by binding to T cells and other immune receptors. B2m-free class I heavy chains (FHCs) form on cells either as a consequence of the natural turnover of pMHC or, in the case of HLA-F, are expressed without β2m. Distinct characteristics of certain HLA-class I members, such as HLA-B27 and HLA-F, stabilize these forms facilitating interactions with immune receptors. FHC forms of HLA-class I have been shown to bind to killer-cell immunoglobulin-like receptor (KIR) family members. The binding of FHC forms to KIR3DL2 regulates natural killer (NK) and T-cell functiona and promotes lymphocyte survival. KIR3DL2 binding to B27 FHC dimers has been implicated in the pathogenesis of spondyloarthritis (SpA). KIR3DL2 binding FHC forms could also play a role in immune cell recognition of certain tumors and in regulation of immune homeostasis at the maternal−fetal interface. Here, I review the evidence for the functional interaction of cell surface HLA-class I FHCs with KIR family members. I also discuss the relevance of these interactions in immune homeostasis and immune dysfunction in diseases in which FHC-binding KIRs have been implicated.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Killer cell immunoglobulin-like receptors; Killer cell immunoglobulin-like receptor 3DL2; Human leukocyte antigen class I free heavy chains; Human leukocyte antigen B27; Human leukocyte antigen F; Ankylosing spondylitis
Publisher: Begell House
ISSN: 1040-8401
Last Modified: 04 Jun 2017 09:51

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