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Clinical studies to broaden the application and improve the safety of Psoralen and ultraviolet A (PUVA) phototherapies

Al-Ismail, Deana 2016. Clinical studies to broaden the application and improve the safety of Psoralen and ultraviolet A (PUVA) phototherapies. MD Thesis, Cardiff University.
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Abstract

This medical doctorate thesis contains clinical studies to broaden the application and to improve the safety and efficacy of ultraviolet (UV) A phototherapies, the main focus being to enhance the current clinical practice of topical psoralen photochemotherapy (PUVA. The thesis includes three studies: 1. The validation of a semi-automated Minimal Phototoxic Dose (MPD) Tester for topical photochemotherapy Thirty seven psoriasis patients referred to the phototherapy unit at St. Woolos, Newport were recruited. Patients had two sets of minimal phototoxic dose (MPD) tests performed on symmetrical, contralateral sites on the lower back. MPD test results from a panel of PUVA-lamps with a UV-opaque template and windows were compared to those from the modified hand-held MPD tester. The hand-held MPD results were linearly related to the PUVA-panel MPD results and this was therefore shown to be a convenient and reliable method of assessing MPD. However, the difference in MPD between the PUVA lamp and the modified handheld MPD tester (CFL TL-10 lamp) was much less than predicted from the PUVA action spectrum of previously published studies suggesting that formal re-evaluation of the erythema action spectrum for PUVA was now appropriate.

Item Type: Thesis (MD)
Status: Unpublished
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Date of First Compliant Deposit: 11 May 2017
Last Modified: 31 Aug 2019 02:26
URI: http://orca-mwe.cf.ac.uk/id/eprint/100479

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