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Anti-transglutaminase 6 autoantibody development in children with celiac disease correlates with duration of gluten exposure

De Leo, Luigina, Aeschlimann, Daniel, Hadjivassiliou, Marios, Aeschlimann, Pascale, Salce, Nicola, Vatta, Serena, Ziberna, Fabiana, Cozzi, Giorgio, Martelossi, Stefano, Ventura, Alessandro and Not, Tarcisio 2018. Anti-transglutaminase 6 autoantibody development in children with celiac disease correlates with duration of gluten exposure. Journal of Pediatric Gastroenterology and Nutrition 66 (1) , pp. 64-68. 10.1097/MPG.0000000000001642

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Objectives: Antibodies against transglutaminase 6 (anti-TG6) have been implicated in neurological manifestations in adult patients with genetic-gluten intolerance and it is unclear whether autoimmunity to TG6 develops following prolonged gluten exposure. We measured the anti-TG6 in children with celiac disease (CD) at the diagnosis time to establish a correlation between these autoantibodies and the duration of gluten exposure. We investigated a correlation between anti-TG6 and the presence of neurological disorders. Methods: Anti-TG6 (IgA/IgG) were measured by ELISA in sera of children with biopsy-proven CD and of children suffering from gastrointestinal disorders. CD-patients positive for anti-TG6 were retested after 2 years of gluten-free diet (GFD). Results: We analyzed the sera of 274 CD-children and of 121 controls. Anti-TG6 were detected in 68/274 (25%) CD-patients and in 19/121 (16%) controls, with significant difference between the two groups (p=0.04). None of the CD-patients and of the controls testing positive for anti-TG6 were suffering from neurological disorders. Eleven/18 (61%) CD-patients with other autoimmune diseases were positive for anti-TG6. In CD-patients a significant correlation between the gluten exposure before the CD-diagnosis and anti-TG6 concentration was found (p=0.006 for IgA; p<0.0001 for IgG). After GFD anti-TG6 concentrations were significantly reduced (p<0.001). No significant correlation was observed between anti-TG6 and anti-TG2 serum concentrations. Conclusions: Anti-TG6 are more prevalent in children with untreated-CD in absence of overt neurological disorders. The synthesis of the anti-TG6 are related to a longer exposure to gluten before the CD diagnosis and the autoimmunity against TG6 is gluten dependent and disappeared during GFD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > RJ Pediatrics
R Medicine > RZ Other systems of medicine
Publisher: Lippincott, Williams & Wilkins
ISSN: 0277-2116
Funders: IRCCS Burlo Garofolo (Grant 03/15) Italy and Ryder Briggs Trust, UK
Date of First Compliant Deposit: 15 May 2017
Date of Acceptance: 6 May 2017
Last Modified: 24 Nov 2020 20:35

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