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Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material

Al Thaher, Yazan, Perni, Stefano and Prokopovich, Polina 2017. Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material. Advances in Colloid and Interface Science 249 , pp. 234-247. 10.1016/j.cis.2017.04.017

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Abstract

Total joint replacement (TJR), such as hip and knee replacement, is a popular procedure worldwide. Prosthetic joint infections (PJI) after this procedure have been widely reported, where treatment of such infections is complex with high cost and prolonged hospital stay. In cemented arthroplasties, the use of antibiotic loaded bone cement (ALBC) is a standard practice for the prophylaxis and treatment of PJI. Recently, the development of bacterial resistance by pathogenic microorganisms against most commonly used antibiotics increased the interest in alternative approaches for antimicrobial delivery systems such as nanotechnology. This review summarizes the efforts made to improve the antimicrobial properties of PMMA bone cements using nanotechnology based antibiotic and non-antibiotic delivery systems to overcome drawbacks of ALBC in the prophylaxis and treatment of PJIs after hip and knee replacement.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: PMMA; Nanotechnology; Bone cement; Nanoparticles; Antimicrobial; TJR; PJI
Publisher: Elsevier
ISSN: 0001-8686
Date of First Compliant Deposit: 2 May 2017
Date of Acceptance: 26 April 2017
Last Modified: 03 Sep 2019 08:23
URI: http://orca-mwe.cf.ac.uk/id/eprint/100228

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